Phenotypes for Atmin Cd79a Tg(IghMyc)22Bri MGI:5755462 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Atmin^tm1.1Jhh/Atmin^tm1.1Jhh Cd79a^tm1(cre)Reth/Cd79a⁺ Tg(IghMyc)22Bri/0
Genetic Background	B6.Cg-Cd79a^tm1(Cre)Reth Atmin^tm1.1Jhh Tg(IghMyc)22Bri

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmin^tm1.1Jhh mutation (2 available); any Atmin mutation (39 available)
Cd79a^tm1(cre)Reth mutation (3 available); any Cd79a mutation (26 available)
Tg(IghMyc)22Bri mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased B cell apoptosis ( J:230105 )

• 15-fold

decreased B cell number ( J:230105 )

• 7.5-fold compared with Tg(IghMyc)22Bri mice

decreased immature B cell number ( J:230105 )

• 60-fold compared with Cd79a^tm1(Cre)Reth/Cd79a⁺ or Tg(IghMyc)22Bri mice

neoplasm

decreased lymphoma incidence ( J:230105 )

• compared with Tg(IghMyc)22Bri mice

increased tumor latency ( J:230105 )

• compared with Tg(IghMyc)22Bri mice

• however, the range to tumor types is the same

cellular

increased B cell apoptosis ( J:230105 )

• 15-fold

hematopoietic system

increased B cell apoptosis ( J:230105 )

• 15-fold

decreased B cell number ( J:230105 )

• 7.5-fold compared with Tg(IghMyc)22Bri mice

decreased immature B cell number ( J:230105 )

• 60-fold compared with Cd79a^tm1(Cre)Reth/Cd79a⁺ or Tg(IghMyc)22Bri mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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