Phenotypes Associated with This Genotype

Genotype
MGI:5751560

• Allelic Composition: Il10^tm1Cgn/Il10^tm1Cgn; Tg(Vil1-cre)997Gum/?; Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

rectal prolapse ( J:229155 )

• 100% of mice develop rectal prolapse by approximately 75 days

abnormal gut flora balance ( J:229155 )

• increase in levels of fecal bacteria as compared to Il10 mutation alone

colitis ( J:229155 )

• severe uniform colitis in 100% of mice; presence of intestinal endothelial cell (IEC)-specific Tlr5 null mutation exacerbates phenotype

• increased incidence of rectal prolapse; presence of IEC-specific Tlr5 null mutation exacerbates phenotype

immune system

colitis ( J:229155 )

• severe uniform colitis in 100% of mice; presence of intestinal endothelial cell (IEC)-specific Tlr5 null mutation exacerbates phenotype

• increased incidence of rectal prolapse; presence of IEC-specific Tlr5 null mutation exacerbates phenotype

mortality/aging

premature death ( J:229155 )

• mice are euthanized due to rectal prolapse