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Phenotypes Associated with This Genotype
Genotype
MGI:5707181
Allelic
Composition
Gt(ROSA)26Sortm2(cre/ERT2)Brn/0
Tg(Sftpc-Grem1)105Mmyl/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(cre/ERT2)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (1062 available)
Tg(Sftpc-Grem1)105Mmyl mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following exposure to silica, the lung tissue of these mice exhibits significantly less inflammatory cell infiltration than that of wild-type mice.

respiratory system
• following exposure to silica, the lung tissue of these mice exhibits significantly less inflammatory cell infiltration than that of wild-type mice.
• at 6 months of age, these mice may exhibit some alveolar space enlargement
• at 6 months of age, these mice exhibit mild septal thickening
• the lungs of these mice exhibit no histologically apparent alterations in fibrosis following exposure to silica


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory