Phenotypes Associated with This Genotype

Genotype
MGI:5703004

• Allelic Composition: Ranbp9^tm1.1Wyan/Ranbp9^tm1.1Wyan
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:222184 )

• only about 6% of mice survive to adulthood

neonatal lethality, incomplete penetrance ( J:222184 )

• neonatal lethality, with about 6% of mice surviving to adulthood

growth/size/body

decreased body size ( J:222184 )

decreased body weight ( J:222184 )

postnatal growth retardation ( J:222184 )

reproductive system

decreased male germ cell number ( J:222184 )

♂ • reduction in total number of spermatogenic cells, however spermatogenesis proceeds through meiosis and reaches round spermatid and even elongated spermatid stages

azoospermia ( J:222184 )

♂ • spermatocytes and spermatids appear to be constantly depleted, leading to a complete lack of spermatozoa in the epididymis

increased male germ cell apoptosis ( J:222184 )

♂ • about 2-fold increase in apoptotic cells, mainly spermatocytes and early round spermatids, in the testes

male infertility ( J:222184 )

♂ • males are completely infertile

cellular

decreased male germ cell number ( J:222184 )

♂ • reduction in total number of spermatogenic cells, however spermatogenesis proceeds through meiosis and reaches round spermatid and even elongated spermatid stages

azoospermia ( J:222184 )

♂ • spermatocytes and spermatids appear to be constantly depleted, leading to a complete lack of spermatozoa in the epididymis

increased male germ cell apoptosis ( J:222184 )

♂ • about 2-fold increase in apoptotic cells, mainly spermatocytes and early round spermatids, in the testes