Phenotypes Associated with This Genotype

Genotype
MGI:5699874

• Allelic Composition: Nf1^tm1Tyj/Nf1⁺; Suz12^{Gt(Betageo)1Khe}/Suz12⁺; Trp53^tm1Tyj/Trp53⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:217077 )

• mice die by 150 days

neoplasm

increased tumor incidence ( J:217077 )

increased lymphoma incidence ( J:217077 )

• 12% of mice develop lymphomas

increased histiocytic sarcoma incidence ( J:217077 )

• 62% of mice develop histiocytic sarcomas

increased neurofibrosarcoma incidence ( J:217077 )

• 38% of mice develop malignant peripheral nerve sheath tumors

• tumors develop on average at 2.3 months of age

increased hemangiosarcoma incidence ( J:217077 )

• 4% of develop angiosarcomas

increased glioma incidence ( J:217077 )

• 54% of mice develop high-grade gliomas

• gliomas develop on average at 3 months of age

nervous system

increased neurofibrosarcoma incidence ( J:217077 )

• 38% of mice develop malignant peripheral nerve sheath tumors

• tumors develop on average at 2.3 months of age

increased glioma incidence ( J:217077 )

• 54% of mice develop high-grade gliomas

• gliomas develop on average at 3 months of age