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Phenotypes Associated with This Genotype
Genotype
MGI:5697630
Allelic
Composition		 Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw
Rag2tm1Fwa/Rag2tm1Fwa
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S/SvEv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(EYFP)Cos mutation (24 available); any Gt(ROSA)26Sor mutation (1243 available)
Pdpk1tm1.1Mlw mutation (0 available); any Pdpk1 mutation (141 available)
Rag2tm1Fwa mutation (46 available); any Rag2 mutation (118 available)
Tnfrsf4tm2(cre)Nik mutation (1 available); any Tnfrsf4 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:226194 )
• mice succumb to disease at 12-16 weeks of age

integument
abnormal keratinocyte differentiation ( J:226194 )
• marker analysis indicates impaired keratinocyte differentiation
dermatitis ( J:226194 )
• mice develop mild skin dermatitis

immune system
dermatitis ( J:226194 )
• mice develop mild skin dermatitis

cellular
abnormal keratinocyte differentiation ( J:226194 )
• marker analysis indicates impaired keratinocyte differentiation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/06/2026
MGI 6.29 		The Jackson Laboratory