Phenotypes for Sugt1 Trp53 MGI:5696984 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Sugt1^{Gt(RRS405)Byg}/Sugt1⁺ Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sugt1^{Gt(RRS405)Byg} mutation (0 available); any Sugt1 mutation (46 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (236 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased tumor-free survival time ( J:226313 )

• significantly longer survival than of p53 knockout mice, but not as long as wild type controls

cellular

cellular phenotype ( J:226313 )

N	• kinetochore formation, spindle checkpoint and ploidy are normal in MEFs • no significant difference in HRas-induced senescence and apoptosis between Sgt1+/ p53 MEF cells and Sgt1+/+ p53/ MEF cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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