Analysis Tools
immune system
| N |
• mice do not exhibit any signs of autoimmune disease
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• during all stages of T cell development except DN1 that does not express the cre transgene
• 10-fold in double positive cells
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• following treatment with CpG-ODNs, mice fail to exhibit an increased in CD4+ and CD8+ single positive T cells compared with wild-type mice
• however, untreated mice exhibit normal T cell proliferation and treated mice do exhibit an increase in macrophages in the spleen and liver as in wild-type mice
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• when stimulated with IL2
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• however, cortical area is normal
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• almost 3-fold
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• in the thymus more so than single conditional knock-outs
• in the blood, lymph nodes and spleen as in Nmt1tm1.1Poru conditional knock-outs
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• at 6 months
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• at 2 and 6 months more so than in either single conditional knock-out
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• CD4+ and CD8+ single positive cells at 2 and 6 months
• following treatment with CpC-ODNs, mice fail to exhibit an increased in CD4+ and CD8+ single positive T cells compared with wild-type mice
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• CD4+ T cells isolated from the lymph nodes and spleen exhibit a shift from naive to activated/memory phenotypes
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• CD8+ T cells isolated from the lymph nodes and spleen exhibit a shift from naive to activated/memory phenotypes
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• in mice sensitized with D-galactosamine hydrochloride and treated with staphylococcal enterotoxin B
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• in mice sensitized with D-galactosamine hydrochloride and treated with staphylococcal enterotoxin B
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• in mice sensitized with D-galactosamine hydrochloride and treated with staphylococcal enterotoxin B
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• after TCR-independent activation
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• after TCR-independent activation
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• mice sensitized with D-galactosamine hydrochloride and treated with staphylococcal enterotoxin B exhibit reduced plasma levels of TNF, IL2 and IFN-gamma compared with wild-type mice
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homeostasis/metabolism
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• in mice sensitized with D-galactosamine hydrochloride and treated with staphylococcal enterotoxin B
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• in mice sensitized with D-galactosamine hydrochloride and treated with staphylococcal enterotoxin B
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• in mice sensitized with D-galactosamine hydrochloride and treated with staphylococcal enterotoxin B
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cellular
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• during all stages of T cell development except DN1 that does not express the cre transgene
• 10-fold in double positive cells
|
|
• following treatment with CpG-ODNs, mice fail to exhibit an increased in CD4+ and CD8+ single positive T cells compared with wild-type mice
• however, untreated mice exhibit normal T cell proliferation and treated mice do exhibit an increase in macrophages in the spleen and liver as in wild-type mice
|
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• when stimulated with IL2
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endocrine/exocrine glands
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• however, cortical area is normal
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• at 6 months
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hematopoietic system
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• during all stages of T cell development except DN1 that does not express the cre transgene
• 10-fold in double positive cells
|
|
• following treatment with CpG-ODNs, mice fail to exhibit an increased in CD4+ and CD8+ single positive T cells compared with wild-type mice
• however, untreated mice exhibit normal T cell proliferation and treated mice do exhibit an increase in macrophages in the spleen and liver as in wild-type mice
|
|
• when stimulated with IL2
|
|
• however, cortical area is normal
|
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• almost 3-fold
|
|
• in the thymus more so than single conditional knock-outs
• in the blood, lymph nodes and spleen as in Nmt1tm1.1Poru conditional knock-outs
|
|
• at 6 months
|
|
• at 2 and 6 months more so than in either single conditional knock-out
|
|
• CD4+ and CD8+ single positive cells at 2 and 6 months
• following treatment with CpC-ODNs, mice fail to exhibit an increased in CD4+ and CD8+ single positive T cells compared with wild-type mice
|
|
• CD4+ T cells isolated from the lymph nodes and spleen exhibit a shift from naive to activated/memory phenotypes
|
|
• CD8+ T cells isolated from the lymph nodes and spleen exhibit a shift from naive to activated/memory phenotypes
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