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Phenotypes Associated with This Genotype
Genotype
MGI:5695608
Allelic
Composition
Tg(Alb-HRAS*G12V)28Yu/0
Genetic
Background
involves: C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice develop hepatic tumors, with incidence lower in females than males (J:107083)
• mice develop multi-centric spontaneous hepatic tumors consisting of both hepatic adenoma and hepatocellular carcinoma (J:238319)
• the tumor feeding vessels can receive blood from both the hepatic artery and portal vein (J:238319)
• 14.3% and 88.2% of males at 6-8 months and older than 9 months of age exhibit hepatocellular carcinoma (J:107083)
• 28.6% of females older than 9 months of age exhibit hepatocellular carcinoma (J:107083)
• 15.4%, 90.5% and 94.1% of males at 2-5 months, 6-8 months, and older than 9 months of age exhibit hepatocellular adenoma, respectively (J:107083)
• 4.5% and 52.4% of females at 6-8 months and older than 9 months of age exhibit hepatocellular adenoma, respectively (J:107083)

liver/biliary system
• mice develop hepatic tumors, with incidence lower in females than males (J:107083)
• mice develop multi-centric spontaneous hepatic tumors consisting of both hepatic adenoma and hepatocellular carcinoma (J:238319)
• the tumor feeding vessels can receive blood from both the hepatic artery and portal vein (J:238319)
• 14.3% and 88.2% of males at 6-8 months and older than 9 months of age exhibit hepatocellular carcinoma (J:107083)
• 28.6% of females older than 9 months of age exhibit hepatocellular carcinoma (J:107083)
• 15.4%, 90.5% and 94.1% of males at 2-5 months, 6-8 months, and older than 9 months of age exhibit hepatocellular adenoma, respectively (J:107083)
• 4.5% and 52.4% of females at 6-8 months and older than 9 months of age exhibit hepatocellular adenoma, respectively (J:107083)
• hepatocytes exhibit cell cycle arrest at the G0/G1 state
• the percentage of apoptosis is higher for female hepatocytes than for male hepatocytes

cellular
• the percentage of apoptosis is higher for female hepatocytes than for male hepatocytes
• ROS production is elevated in both male and female hepatocytes, although the increase is higher in males than females

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hepatocellular carcinoma DOID:684 OMIM:114550
J:107083 , J:238319


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory