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Phenotypes Associated with This Genotype
Genotype
MGI:5688868
Allelic
Composition		 Pkn3tm1.1Mrl/Pkn3+
Ptentm1Hwu/Ptentm1Hwu
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkn3tm1.1Mrl mutation (0 available); any Pkn3 mutation (55 available)
Ptentm1Hwu mutation (17 available); any Pten mutation (86 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:216983 )
• lifespan after pIpC treatment is shorter than in controls and in mutant nice with no wild-type Pkn3 alleles

neoplasm
increased hemolymphoid system tumor incidence ( J:216983 )
• develop myeloproliferative neoplasms in the spleen 2 weeks after pIpC treatment
increased acute lymphoblastic leukemia incidence ( J:216983 )
• all eventually develop T cell acute lymphoblastic leukemia after pIpC treatment at 6 weeks of age

hematopoietic system
enlarged thymus ( J:216983 )
• at 2 weeks after pIpC treatment
enlarged spleen ( J:216983 )
• at 2 weeks after pIpC treatment
extramedullary hematopoiesis ( J:216983 )
• increase in the number of hematopoietic stem cells in the spleen 2 weeks after pIpC treatment

endocrine/exocrine glands
enlarged thymus ( J:216983 )
• at 2 weeks after pIpC treatment

immune system
enlarged thymus ( J:216983 )
• at 2 weeks after pIpC treatment
enlarged spleen ( J:216983 )
• at 2 weeks after pIpC treatment

growth/size/body
enlarged spleen ( J:216983 )
• at 2 weeks after pIpC treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory