Analysis Tools
reproductive system
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• lack appreciable levels of round and elongated postmeiotic spermatids
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azoospermia
(
J:216246
)
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• epididymides are devoid of mature spermatozoa
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• lack appreciable levels of round and elongated postmeiotic spermatids
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• about 20% of tubules contain multiple apoptotic cells
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• most tubules are highly vacuolized
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small testis
(
J:216246
)
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• severe reduction in size
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• severe reduction in weight
• weight is similar to controls at P14 but reduced by 3 weeks of age
• weigh only 30% of wild-type at 8 weeks of age
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• arrest at the late pachytene stage
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• absence of markers for post-meiotic cells indicates a block in male meiosis
• no diplotene or later stages of meiosis are seen indicating a failure to progress beyond the pachytene stage of meiosis
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• males, but not females, are infertile
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endocrine/exocrine glands
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• most tubules are highly vacuolized
|
small testis
(
J:216246
)
|
|
• severe reduction in size
|
|
|
• severe reduction in weight
• weight is similar to controls at P14 but reduced by 3 weeks of age
• weigh only 30% of wild-type at 8 weeks of age
|
cellular
|
|
• lack appreciable levels of round and elongated postmeiotic spermatids
|
azoospermia
(
J:216246
)
|
|
• epididymides are devoid of mature spermatozoa
|
|
|
• lack appreciable levels of round and elongated postmeiotic spermatids
|
|
|
• absence of markers for post-meiotic cells indicates a block in male meiosis
• no diplotene or later stages of meiosis are seen indicating a failure to progress beyond the pachytene stage of meiosis
|
|
|
• about 20% of tubules contain multiple apoptotic cells
|
