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Phenotypes Associated with This Genotype
Genotype
MGI:5660926
Allelic
Composition
Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho/Disc1+
Genetic
Background
(129S2/SvPasCrl x C57BL)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho mutation (1 available); any Disc1 mutation (67 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• males show a larger increase in total distance traveled, counts, and transitions in locomotion after ketamine injection than sibling controls
• mice show a large startle variation between individuals with a significant number of mice with low startle (<50)
• however, prepulse inhibition and habituation of acoustic startle are normal


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory