Phenotypes Associated with This Genotype

Genotype
MGI:5660197

• Allelic Composition: Mapk1^tm1Gela/Mapk1^tm1Gela; Mapk3^tm1Gela/Mapk3^tm1Gela; H2az2^{Tg(Wnt1-cre)11Rth}/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

absent mandible ( J:144862 )

short maxilla ( J:144862 )

• more severe than in mice heterozygous for Mapk3^tm1Gela

small pharyngeal arch ( J:144862 )

• at E10.5

absent tongue ( J:144862 )

absent outer ear ( J:144862 )

growth/size/body

absent mandible ( J:144862 )

short maxilla ( J:144862 )

• more severe than in mice heterozygous for Mapk3^tm1Gela

absent tongue ( J:144862 )

absent outer ear ( J:144862 )

decreased body length ( J:144862 )

cardiovascular system

persistent truncus arteriosus ( J:144862 )

• in 5 of 5 mice at E16.5 and E17.5

ventricular septal defect ( J:144862 )

• in 5 of 5 mice at E16.5 and E17.5

endocrine/exocrine glands

athymia ( J:144862 )

abnormal thyroid gland morphology ( J:144862 )

• singled-lobed and medially localized

digestive/alimentary system

absent tongue ( J:144862 )

embryo

small pharyngeal arch ( J:144862 )

• at E10.5

hearing/vestibular/ear

absent outer ear ( J:144862 )

hematopoietic system

athymia ( J:144862 )

immune system

athymia ( J:144862 )

skeleton

absent mandible ( J:144862 )

short maxilla ( J:144862 )

• more severe than in mice heterozygous for Mapk3^tm1Gela

vision/eye

abnormal eye distance/ position ( J:144862 )