Phenotypes Associated with This Genotype

Genotype
MGI:5660196

• Allelic Composition: Mapk1^tm1Gela/Mapk1^tm1Gela; Mapk3^tm1Gela/Mapk3⁺; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

mandible hypoplasia ( J:144862 )

• more severe than in mice with normal Mapk3

short maxilla ( J:144862 )

• more severe than in mice with normal Mapk3

cleft palate ( J:144862 )

• more severe than in mice with normal Mapk3

absent tongue ( J:144862 )

craniofacial

mandible hypoplasia ( J:144862 )

• more severe than in mice with normal Mapk3

short maxilla ( J:144862 )

• more severe than in mice with normal Mapk3

cleft palate ( J:144862 )

• more severe than in mice with normal Mapk3

absent tongue ( J:144862 )

cardiovascular system

persistent truncus arteriosus ( J:144862 )

• in 3 of 3 mice at E16.5 and E17.5

ventricular septal defect ( J:144862 )

• in 3 of 3 mice at E16.5 and E17.5

endocrine/exocrine glands

abnormal thymus morphology ( J:144862 )

• single-lobed, fused and misplaced

abnormal thyroid gland morphology ( J:144862 )

• singled-lobed and medially localized

digestive/alimentary system

cleft palate ( J:144862 )

• more severe than in mice with normal Mapk3

absent tongue ( J:144862 )

hematopoietic system

abnormal thymus morphology ( J:144862 )

• single-lobed, fused and misplaced

immune system

abnormal thymus morphology ( J:144862 )

• single-lobed, fused and misplaced

skeleton

mandible hypoplasia ( J:144862 )

• more severe than in mice with normal Mapk3

short maxilla ( J:144862 )

• more severe than in mice with normal Mapk3

vision/eye

abnormal eye distance/ position ( J:144862 )