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Phenotypes Associated with This Genotype
Genotype
MGI:5659895
Allelic
Composition		 Cdkn2atm1Rdp/Cdkn2atm1Rdp
Krastm4Tyj/Kras+
Genetic
Background		 involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation (6 available); any Cdkn2a mutation (62 available)
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:124682 )
• mice inoculated with an adenovirus expressing cre recombinase (ad-cre) by inhalation have a median survival of 22 weeks after ad-cre inoculation

neoplasm
increased lung adenocarcinoma incidence ( J:124682 )
• mice inoculated with ad-cre by inhalation develop lung adenocarcinomas with high multiplicity, however metastasis is not observed

respiratory system
increased lung adenocarcinoma incidence ( J:124682 )
• mice inoculated with ad-cre by inhalation develop lung adenocarcinomas with high multiplicity, however metastasis is not observed

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory