Phenotypes for Cpa3 Fgfr1 Fgfr2 Tg(KRT5-cre)5132Jlj MGI:5642134 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cpa3^tm3(icre)Hrr/Cpa3⁺ Fgfr1^tm1Upir/Fgfr1^tm1Upir Fgfr2^tm1Dor/Fgfr2^tm1Dor Tg(KRT5-cre)5132Jlj/0
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpa3^tm3(icre)Hrr mutation (0 available); any Cpa3 mutation (29 available)
Fgfr1^tm1Upir mutation (0 available); any Fgfr1 mutation (218 available)
Fgfr2^tm1Dor mutation (3 available); any Fgfr2 mutation (88 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:221184 )

integument

increased keratinocyte proliferation ( J:221184 )

impaired skin barrier function ( J:221184 )

• increase in transepidermal water loss, indicating an epidermal barrier defect

skin inflammation ( J:221184 )

progressive hair loss ( J:221184 )

acanthosis ( J:221184 )

hematopoietic system

absent mast cells ( J:221184 )

homeostasis/metabolism

impaired skin barrier function ( J:221184 )

• increase in transepidermal water loss, indicating an epidermal barrier defect

immune system

absent mast cells ( J:221184 )

skin inflammation ( J:221184 )

cellular

increased keratinocyte proliferation ( J:221184 )

reproductive system

female infertility ( J:221184 )

• all females are sterile

reduced male fertility ( J:221184 )

• most males are sterile

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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