Analysis Tools
behavior/neurological
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• mice show reduced investigation of social odors compared with controls, suggesting impaired discrimination of social olfactory cues
• however, mice show normal investigation of non-social olfactory cues
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• increase in self-grooming rates
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• mice show impaired male-female social interactions, with reductions in the time that mice spend interacting compared to controls
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• in a 3-chambered assay of social approach and preference for social novelty, mice exhibit social impairments, showing no differences between the time spend in the chamber or in interaction with the novel mouse versus the novel object unlike controls
• in a social novelty paradigm, mice show no preference for social novelty
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• P5-P12 pups show increased vocalizations
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nervous system
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• increase in spine density on Purkinje cell dendrites
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• Purkinje cell excitability is reduced, with Purkinje cells showing lower, graded spontaneous spiking rate, and current injection evokes fewer action potentials in Purkinje cells
• injection of small hyperpolarizing currents results in smaller voltage changes in Purkinje cells, indicating a decrease in the effective input resistance
• despite receiving normal functioning synaptic inputs, the output of the cerebellar cortex is reduced, both tonically and in response to incoming excitatory drive
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