Phenotypes for Cdh1 Smad4 Tg(Pdx1-cre)6Tuv Trp53 MGI:5634407 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cdh1^tm2Kem/Cdh1^tm2Kem Smad4^tm2.1Cxd/Smad4^tm2.1Cxd Trp53^tm1Brn/Trp53^tm1Brn Tg(Pdx1-cre)6Tuv/0
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh1^tm2Kem mutation (1 available); any Cdh1 mutation (173 available)
Smad4^tm2.1Cxd mutation (3 available); any Smad4 mutation (46 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53^tm1Brn mutation (20 available); any Trp53 mutation (237 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased gastric adenocarcinoma incidence ( J:212549 )

• mice develop gastric adenocarcinomas with a median tumor-free survival of 9.4 months but do not develop distant metastases

digestive/alimentary system

increased gastric adenocarcinoma incidence ( J:212549 )

• mice develop gastric adenocarcinomas with a median tumor-free survival of 9.4 months but do not develop distant metastases

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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