Phenotypes Associated with This Genotype

Genotype
MGI:5634400

• Allelic Composition: Cdh1^tm2Kem/Cdh1⁺; Smad4^tm2.1Cxd/Smad4^tm2.1Cxd; Trp53^tm1Brn/Trp53^tm1Brn; Tg(Pdx1-cre)6Tuv/0
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:212549 )

• most common cause of death is duodenal obstruction, followed by gastric outlet obstruction

neoplasm

increased duodenum adenocarcinoma incidence ( J:212549 )

• 36% of mice develop duodenal adenocarcinomas

increased gastric adenocarcinoma incidence ( J:212549 )

• 84% of mice develop spontaneous tumors in the glandular stomach with a median tumor-free survival of 8 months

• gastric tumors resemble diffuse-type gastric adenocarcinomas, are E-cadherin-negative, and are invasive into the muscle layers and regional lymph nodes

• intramucosal adenocarcinomas with signet ring cell feature is seen in 2 of 4 mice at 6 months of age

• gastric premalignant lesions such as atrophic gastritis, metaplasia or dysplasia are not seen at 4 and 5 months of age

increased metastatic potential ( J:212549 )

• 3 of 21 mice with gastric adenocarcinomas develop lung metastases

• metastatic lesions have similar cytologic features to primary gastric tumors

• 8% of mice exhibit adenocarcinomas in the pancreas, most likely due to invasion of the primary duodenal or gastric adenocarcinomas

increased squamous cell carcinoma incidence ( J:212549 )

• 24% of mice develop forestomach squamous cell carcinomas

digestive/alimentary system

increased duodenum adenocarcinoma incidence ( J:212549 )

• 36% of mice develop duodenal adenocarcinomas

increased gastric adenocarcinoma incidence ( J:212549 )

• 84% of mice develop spontaneous tumors in the glandular stomach with a median tumor-free survival of 8 months

• gastric tumors resemble diffuse-type gastric adenocarcinomas, are E-cadherin-negative, and are invasive into the muscle layers and regional lymph nodes

• intramucosal adenocarcinomas with signet ring cell feature is seen in 2 of 4 mice at 6 months of age

• gastric premalignant lesions such as atrophic gastritis, metaplasia or dysplasia are not seen at 4 and 5 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
stomach cancer		DOID:10534	OMIM:613659	J:212549