Analysis Tools
liver/biliary system
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• mice exhibit biliary lesions
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• mice exhibit necrotic liver injury (three types of injury are seen) which is maximal at 6-8 weeks of age
• 34% of mice exhibit few white liver lesions identified as necrotic areas (type I liver)
• 40% of mice exhibit multilocular, visible white liver lesions with features of parenchymal necroses or bile infarcts and increased liver weight (type II liver)
• 26% of mice exhibit yellow livers, increased liver size, multilocular yellow lesions resulting in massive necrotic destruction of the liver associated with multiple bile infarcts, and exhibit dwarfism (type III liver)
• increase in cell proliferation (not hepatocytes) in the liver
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• mice exhibit necrotic liver injury which is maximal at 6-8 weeks of age
• ageing mice recover from necrotic liver injury and are protected from steatosis but develop liver fibrosis
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• hepatomegaly is seen in mice with type II and III livers
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• ageing mice recover from necrotic liver injury but develop liver fibrosis
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growth/size/body
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• dwarfism is seen in mice with type III livers
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• hepatomegaly is seen in mice with type II and III livers
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homeostasis/metabolism
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• increase in bilirubin levels in mice with type III livers
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• serum transaminase levels are increased in mice with type II and III livers
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• alkaline phosphatase levels are elevated in correlation to severity of liver injury
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• increase in bile acid levels in mice with type III livers
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neoplasm
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N |
• mice do not develop hepatocellular carcinoma are remain tumor free up to 60 weeks of age
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cellular
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• mice exhibit necrotic liver injury which is maximal at 6-8 weeks of age
• ageing mice recover from necrotic liver injury and are protected from steatosis but develop liver fibrosis
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