Phenotypes Associated with This Genotype

Genotype
MGI:5614426

• Allelic Composition: Chn1^tm1Ito/Chn1^tm1.1Ito; Tg(Slc17a6-icre)1Oki/0
• Genetic Background: involves: C57BL/6 * C57BL/6NSlc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal gait ( J:209606 )

• quadrupedal hopping gait is dominant at all locomotor frequencies

• occasional alternating gait is seen at lower frequencies, occurrence of alternating gait is increased compared to mice heterozygous for Epha4 ^tm1.1Bzh Epha4^tm1.2Bzh and hemizygous for Tg(Slc17a6-icre)1Oki

nervous system

abnormal spinal cord morphology ( J:209606 )

• significantly wider gap between the central canal and the ventral edge of the dorsal funiculus

abnormal nerve fiber response ( J:209606 )

• chemically and electrically stimulated locomotor-like activity in isolated spinal cord preparations induces a synchronous "hopping" locomotor-like activity rather than an alternating locomotor-like activity