Phenotypes Associated with This Genotype

Genotype
MGI:5604750

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Tg(CAG-Bgeo,-tsA58T)T26Ichi/0; Tg(Pdx1-cre)6Tuv/0
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:214846 )

• mice do not survive beyond P21

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:214846 )

• mice develop highly aggressive adenocarcinoma with a ductal cell phenotype and inflammation resembling human pancreatic ductal adenocarcinoma within a short period (5 and 10 days after birth) and die within 3 weeks

• at P16, pancreatic ductal adenocarcinoma progresses to occupy the whole pancreas and to invade the muscular wall of the duodenum

increased pancreatic intraepithelial neoplasia incidence ( J:214846 )

• PanIN-3 are detected in the pancreas with inflammation at P3 and P4

endocrine/exocrine glands

pancreatic acinar-to-ductal metaplasia ( J:214846 )

• invasive features of pancreatic ductal adenocarcinoma are seen containing acinoductal metaplasia at P5-P10

increased pancreatic ductal adenocarcinoma incidence ( J:214846 )

• mice develop highly aggressive adenocarcinoma with a ductal cell phenotype and inflammation resembling human pancreatic ductal adenocarcinoma within a short period (5 and 10 days after birth) and die within 3 weeks

• at P16, pancreatic ductal adenocarcinoma progresses to occupy the whole pancreas and to invade the muscular wall of the duodenum

increased pancreatic intraepithelial neoplasia incidence ( J:214846 )

• PanIN-3 are detected in the pancreas with inflammation at P3 and P4

homeostasis/metabolism

hemorrhagic ascites ( J:214846 )

• hemorrhagic ascites are seen by P16

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic carcinoma		DOID:4905	OMIM:260350	J:214846