Phenotypes Associated with This Genotype

Genotype
MGI:5576532

• Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1⁺; Cxcr4^tm2Yzo/Cxcr4^tm2Yzo; Tg(Wap-cre)11738Mam/0; Tg(Wap-Hgf)402Mig/0
• Genetic Background: FVB.Cg-Cxcr4^tm2Yzo Ctnnb1^tm1Mmt Tg(Wap-cre)11738Mam Tg(Wap-Hgf)402Mig

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased mammary gland tumor incidence in breeding females ( J:206839 )

♀ • appearance of mammary tumors in postpartum females is delayed compared to triple Ctnnb1^tm1Mmt Tg(Wap-cre)11738Mam Tg(Wap-Hgf)402Mig mutants, with tumors developing at 7 weeks postpartum rather than 2 weeks

♀ • tumors are smaller in females 2 weeks postpartum than in triple mutants

endocrine/exocrine glands

decreased mammary gland tumor incidence in breeding females ( J:206839 )

♀ • appearance of mammary tumors in postpartum females is delayed compared to triple Ctnnb1^tm1Mmt Tg(Wap-cre)11738Mam Tg(Wap-Hgf)402Mig mutants, with tumors developing at 7 weeks postpartum rather than 2 weeks

♀ • tumors are smaller in females 2 weeks postpartum than in triple mutants

integument

decreased mammary gland tumor incidence in breeding females ( J:206839 )

♀ • appearance of mammary tumors in postpartum females is delayed compared to triple Ctnnb1^tm1Mmt Tg(Wap-cre)11738Mam Tg(Wap-Hgf)402Mig mutants, with tumors developing at 7 weeks postpartum rather than 2 weeks

♀ • tumors are smaller in females 2 weeks postpartum than in triple mutants