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Phenotypes Associated with This Genotype
Genotype
MGI:5575661
Allelic
Composition
Asxl1tm1.1Iaai/Asxl1tm1.1Iaai
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129S/SvEv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Asxl1tm1.1Iaai mutation (1 available); any Asxl1 mutation (104 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• 6 month old mice show dysplasia of circulating myeloid cells following pI:pC treatment
• mice treated with polyinosinicpolycytidylic acid (pI:pC) show infiltration of liver with hematopoietic cells, indicating extramedullary hematopoiesis
• 1.4- to 2-fold increase in CD71+/Ter119- erythoroid precursor cells in the bone marrow and spleen following pI:pC treatment, indicating impaired erythroid differentiation
• hemoglobin is reduced at between 6 and 12 months of age after pI:pC treatment, but not in younger mice
• following pI:pC treatment, mice show frequent circulating nucleated red cells at 6 months of age
• following pI:pC treatment, mice develop progressive leukopenia that is most apparent at 6-12 months of age
• leukopenia is predominately as a result of decreased B220+ mature B cells, CD11b+Gr1+ neutrophils, and CD11b+Gr1- monocytes
• decrease in CD11b+Gr1+ neutrophils following pI:pC treatment
• mice show a decrease in B220+ mature B cells following pI:pC treatment
• decrease in CD11b+Gr1- monocytes following pI:pC treatment

immune system
• 6 month old mice show dysplasia of circulating myeloid cells following pI:pC treatment
• following pI:pC treatment, mice develop progressive leukopenia that is most apparent at 6-12 months of age
• leukopenia is predominately as a result of decreased B220+ mature B cells, CD11b+Gr1+ neutrophils, and CD11b+Gr1- monocytes
• decrease in CD11b+Gr1+ neutrophils following pI:pC treatment
• mice show a decrease in B220+ mature B cells following pI:pC treatment
• decrease in CD11b+Gr1- monocytes following pI:pC treatment

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
myelodysplastic syndrome DOID:0050908 OMIM:614286
J:208092


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory