Phenotypes Associated with This Genotype

Genotype
MGI:5567931

• Allelic Composition: Gt(ROSA)26Sor^{tm2(Lmp1/CD40)Uzs}/Gt(ROSA)26Sor⁺; Cd19^tm1(cre)Cgn/Cd19⁺
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Gt(ROSA)26Sor^{tm2(Lmp1/CD40)Uzs}/Gt(ROSA)26Sor⁺ Cd19^tm1(cre)Cgn/Cd19⁺ mice develop mono- and oligoclonal lymphomas

immune system

enlarged spleen ( J:137122 )

• at 8 weeks

• extreme in mice older than 12 months showing signs of disease

increased spleen weight ( J:137122 )

• 3.5-fold at 8 weeks

• 20- to 40-fold in mice older than 12 months showing signs of disease

increased B cell number ( J:137122 )

• 8 times more in the spleen

• 4-fold in lymph nodes

• increased percent of IgM+IgD+ B cells in the spleen and lymph nodes

• however, absolute numbers in the bone marrow are normal

increased follicular B cell number ( J:137122 )

increased marginal zone B cell number ( J:137122 )

increased T cell number ( J:137122 )

• 3 times more in the spleen

increased spleen B cell follicle size ( J:137122 )

• enlarged

abnormal B cell physiology ( J:137122 )

• prolonged survival in vitro

abnormal class switch recombination ( J:137122 )

• Ig class switch recombination is achieved in the presence of IL4 indicating constitutive CD40 signaling

abnormal B cell activation ( J:137122 )

• activated B cells in the spleen and lymph node

increased B cell proliferation ( J:137122 )

• spontaneous

abnormal T cell activation ( J:137122 )

• activated T cells with a shift toward activated and memory-type T cells

enlarged inguinal lymph nodes ( J:137122 )

• in mice older than 12 months showing signs of disease

abnormal humoral immune response ( J:137122 )

• following immunization with hapten conjugated to the carrier chicken gammaglobulin, mice exhibit reduced recruitment/maintenance of B cells within the germinal centers of the spleen compared with wild-type mice

neoplasm

increased B cell derived lymphoma incidence ( J:137122 )

• with extreme splenomegaly, enlarged inguinal lymph nodes, hepatomegaly and nodular infiltrates in the kidney, lung and liver in mice older than 12 months showing signs of disease

liver/biliary system

enlarged liver ( J:137122 )

• in mice older than 12 months showing signs of disease

hematopoietic system

enlarged spleen ( J:137122 )

• at 8 weeks

• extreme in mice older than 12 months showing signs of disease

increased spleen weight ( J:137122 )

• 3.5-fold at 8 weeks

• 20- to 40-fold in mice older than 12 months showing signs of disease

increased B cell number ( J:137122 )

• 8 times more in the spleen

• 4-fold in lymph nodes

• increased percent of IgM+IgD+ B cells in the spleen and lymph nodes

• however, absolute numbers in the bone marrow are normal

increased follicular B cell number ( J:137122 )

increased marginal zone B cell number ( J:137122 )

increased T cell number ( J:137122 )

• 3 times more in the spleen

increased spleen B cell follicle size ( J:137122 )

• enlarged

abnormal B cell physiology ( J:137122 )

• prolonged survival in vitro

abnormal class switch recombination ( J:137122 )

• Ig class switch recombination is achieved in the presence of IL4 indicating constitutive CD40 signaling

abnormal B cell activation ( J:137122 )

• activated B cells in the spleen and lymph node

increased B cell proliferation ( J:137122 )

• spontaneous

abnormal T cell activation ( J:137122 )

• activated T cells with a shift toward activated and memory-type T cells

growth/size/body

enlarged liver ( J:137122 )

• in mice older than 12 months showing signs of disease

enlarged spleen ( J:137122 )

• at 8 weeks

• extreme in mice older than 12 months showing signs of disease

increased spleen weight ( J:137122 )

• 3.5-fold at 8 weeks

• 20- to 40-fold in mice older than 12 months showing signs of disease

cellular

increased B cell proliferation ( J:137122 )

• spontaneous