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Phenotypes Associated with This Genotype
Genotype
MGI:5564909
Allelic
Composition		 Bcl11atm1Pwt/Bcl11atm1Pwt
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11atm1Pwt mutation (0 available); any Bcl11a mutation (42 available)
Gt(ROSA)26Sortm1(EYFP)Cos mutation (23 available); any Gt(ROSA)26Sor mutation (1095 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal dendritic cell differentiation ( J:207383 )
• following pIpC induction cultured precursor cells fail to produce plasmacytoid dendritic cells

hematopoietic system
abnormal dendritic cell differentiation ( J:207383 )
• following pIpC induction cultured precursor cells fail to produce plasmacytoid dendritic cells
decreased dendritic cell number ( J:207383 )
• mild decrease in the total number of cells in GM-CSF-supplemented cultures following pIpC treatment
decreased plasmacytoid dendritic cell number ( J:207383 )
• following pIpC induction cultured precursor cells fail to produce plasmacytoid dendritic cells and in vivo
decreased B cell number ( J:207383 )
• in Flt3L-supplemented cultures following pIpC induced deletion in hematopoietic stem cells and in vivo

immune system
abnormal dendritic cell differentiation ( J:207383 )
• following pIpC induction cultured precursor cells fail to produce plasmacytoid dendritic cells
decreased dendritic cell number ( J:207383 )
• mild decrease in the total number of cells in GM-CSF-supplemented cultures following pIpC treatment
decreased plasmacytoid dendritic cell number ( J:207383 )
• following pIpC induction cultured precursor cells fail to produce plasmacytoid dendritic cells and in vivo
decreased B cell number ( J:207383 )
• in Flt3L-supplemented cultures following pIpC induced deletion in hematopoietic stem cells and in vivo

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory