Phenotypes Associated with This Genotype

Genotype
MGI:5559577

• Allelic Composition: Kmt2a^{tm1.1(Sh3gl1)Lcc}/Kmt2a⁺; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:205605 )

• 50% survival at 6 months

immune system

enlarged spleen ( J:205605 )

• in some mice

myeloid hyperplasia ( J:205605 )

• increased immature myeloid cell population in the bone marrow, spleen and liver

enlarged lymph nodes ( J:205605 )

• in some mice

neoplasm

increased leukemia incidence ( J:205605 )

• acute myeloid leukemia after 12 months in some mice

• however, suppression of Prmt1 reduces leukemic cells

liver/biliary system

enlarged liver ( J:205605 )

• in some mice

hematopoietic system

enlarged spleen ( J:205605 )

• in some mice

myeloid hyperplasia ( J:205605 )

• increased immature myeloid cell population in the bone marrow, spleen and liver

growth/size/body

enlarged liver ( J:205605 )

• in some mice

enlarged spleen ( J:205605 )

• in some mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
leukemia		DOID:1240		J:205605