Phenotypes for Gt(ROSA)26Sor Tbx1 MGI:5551753 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem} Tbx1^tm6(cre)Bld/Tbx1⁺
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem} mutation (1 available); any Gt(ROSA)26Sor mutation (1098 available)
Tbx1^tm6(cre)Bld mutation (1 available); any Tbx1 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Heart development defects in Tbx1^tm6(cre)Bld/Tbx1⁺ Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem} mice

mortality/aging

postnatal lethality, complete penetrance ( J:204435 )

• no mice are present at P10

cardiovascular system

persistent truncus arteriosus ( J:204435 )

• in 2 of 5 mice

double outlet right ventricle ( J:204435 )

• in 3 of 5 mice

ventricular septal defect ( J:204435 )

• in all mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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