Phenotypes Associated with This Genotype

Genotype
MGI:5550380

• Allelic Composition: Rnf31^tm1.1Kiwa/Rnf31^tm1.1Kiwa; Cd79a^tm1(cre)Reth/Cd79a⁺
• Genetic Background: involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:201885 )

N • mice exhibit normal conventional B cell development and I cell populations

abnormal B-1 B cell morphology ( J:201885 )

• severely impaired B1 B cell development in the peritoneal cavity

decreased B-1a cell number ( J:201885 )

• in the peritoneal cavity

decreased B-1b cell number ( J:201885 )

• in the peritoneal cavity

abnormal humoral immune response ( J:201885 )

• impaired antibody responses to both T cell-dependent and T cell-independent type 2 antigens

decreased IgA level ( J:201885 )

• in unimmunized mice

decreased IgG1 level ( J:201885 )

• in unimmunized mice

• in mice immunized with NP-CGG

decreased IgG2a level ( J:201885 )

• in unimmunized mice

decreased IgG2b level ( J:201885 )

• in unimmunized mice

decreased IgG3 level ( J:201885 )

• in unimmunized mice

• in mice immunized with NP-Ficoll

decreased IgM level ( J:201885 )

• in unimmunized mice

• in mice immunized with NP-CGG or NP-Ficoll

hematopoietic system

abnormal B-1 B cell morphology ( J:201885 )

• severely impaired B1 B cell development in the peritoneal cavity

decreased B-1a cell number ( J:201885 )

• in the peritoneal cavity

decreased B-1b cell number ( J:201885 )

• in the peritoneal cavity

decreased IgA level ( J:201885 )

• in unimmunized mice

decreased IgG1 level ( J:201885 )

• in unimmunized mice

• in mice immunized with NP-CGG

decreased IgG2a level ( J:201885 )

• in unimmunized mice

decreased IgG2b level ( J:201885 )

• in unimmunized mice

decreased IgG3 level ( J:201885 )

• in unimmunized mice

• in mice immunized with NP-Ficoll

decreased IgM level ( J:201885 )

• in unimmunized mice

• in mice immunized with NP-CGG or NP-Ficoll