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Phenotypes Associated with This Genotype
Genotype
MGI:5546509
Allelic
Composition
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Msx2-rtTA)885Lma/0
Tg(tetO-cre)1Jaw/0
Genetic
Background
involves: 129 * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (18 available)
Tg(Msx2-rtTA)885Lma mutation (0 available)
Tg(tetO-cre)1Jaw mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• mutants on a doxycycline diet exhibit craniofacial malformations (J:202618)
• mutants on a doxycycline diet exhibit craniofacial malformations (J:202618)

integument
• mutants on a doxycycline diet exhibit alopecia (J:202618)
• mutants on a doxycycline diet exhibit alopecia (J:202618)

mortality/aging
• 35% of mutants on a doxycycline diet for at least 3 weeks starting at P25 die during the 12 weeks following doxycycline administration; males and females die at similar rates (J:202618)
• 35% of mutants on a doxycycline diet for at least 3 weeks starting at P25 die during the 12 weeks following doxycycline administration; males and females die at similar rates (J:202618)

renal/urinary system
• urothelia of males on the doxycycline diet is more severely affected than in females (J:202618)
• increase in urothelial basal cell proliferation is seen in mutants fed doxycycline (J:202618)
• bladders of males 5 weeks after doxycline treatment show a higher proliferation index than females at the same stage (J:202618)
• urothelia of males on the doxycycline diet is more severely affected than in females (J:202618)
• increase in urothelial basal cell proliferation is seen in mutants fed doxycycline (J:202618)
• bladders of males 5 weeks after doxycline treatment show a higher proliferation index than females at the same stage (J:202618)

tumorigenesis
• 24% of the remaining surviving mutants on a doxycycline diet for at least 3 weeks starting at P25 exhibit tumors within the bladder lumen; 11 mutants have single tumor and 18 have multifoci tumors (J:202618)
• tumors in doxycline fed mutants resemble low-grade papillary urothelial carcinoma, exhibit polypoid structure, and the urothelium has lost its typical polarity and shows nuclear atypia, high mitogenic activity, and vascular infiltration (J:202618)
• however, no nuclear pleomorphism or muscle invasion is seen (J:202618)
• 45% of males on the doxycycline diet develop bladder tumors compared to 3% of females on the diet (J:202618)
• only 12.5% of castrated males after 3 months of doxycycline treatment develop luminal tumors and cell proliferation is 20% less than in noncastrated males (J:202618)
• 24% of the remaining surviving mutants on a doxycycline diet for at least 3 weeks starting at P25 exhibit tumors within the bladder lumen; 11 mutants have single tumor and 18 have multifoci tumors (J:202618)
• tumors in doxycline fed mutants resemble low-grade papillary urothelial carcinoma, exhibit polypoid structure, and the urothelium has lost its typical polarity and shows nuclear atypia, high mitogenic activity, and vascular infiltration (J:202618)
• however, no nuclear pleomorphism or muscle invasion is seen (J:202618)
• 45% of males on the doxycycline diet develop bladder tumors compared to 3% of females on the diet (J:202618)
• only 12.5% of castrated males after 3 months of doxycycline treatment develop luminal tumors and cell proliferation is 20% less than in noncastrated males (J:202618)

Mouse Models of Human Disease
OMIM ID Ref(s)
Bladder Cancer 109800 J:202618


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory