Phenotypes for Apc Cd44 MGI:5544115 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Apc^Min/Apc⁺ Cd44^tm1Mak/Cd44^tm1Mak
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (151 available)
Cd44^tm1Mak mutation (1 available); any Cd44 mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased tumor-free survival time ( J:204874 )

• mice survive longer than Apc^Min heterozygotes

neoplasm

decreased intestinal adenoma incidence ( J:204874 )

• decreased adenoma and microadenoma compared with Apc^Min heterozygotes without a change in intestinal crypt apoptosis and proliferation rates

digestive/alimentary system

increased enterocyte apoptosis ( J:204874 )

• compared with Apc^Min heterozygotes

decreased intestinal adenoma incidence ( J:204874 )

• decreased adenoma and microadenoma compared with Apc^Min heterozygotes without a change in intestinal crypt apoptosis and proliferation rates

cellular

increased enterocyte apoptosis ( J:204874 )

• compared with Apc^Min heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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