Analysis Tools
immune system
|
• HIV-infected BLT transplanted mice exhibit a loss of CD4+ T cells and an increase in CD8+ T cells
|
|
• a high proportion of CD38+ CD8+ T cells appear activated in HIV-infected BLT transplanted mice
|
|
• spleen and lymph nodes lack lymphocytes
|
|
• HIV-infected BLT transplanted mice exhibit a loss of CD4+ T cells and an increase in CD8+ T cells
|
|
• mice fail to develop peripheral lymph nodes
|
|
• 54% of BLT transplanted mice inoculated intrarectally with HIV become infected with plasma viral titers peaking between 2 and 4 weeks
• 100% of transplanted mice inoculated intraperitoneally with HIV become infected
• HIV-infected BLT transplanted mice exhibit a loss of CD4+ T cells and an increase in CD8+ T cells
• a high proportion of CD8+ T cells appear activated in HIV-infected BLT transplanted mice
• infected mice produce HIV-specific antibodies and can mount HIV-specific T cell responses
|
|
• mice are tolerized to xenotransplantation with human bone marrow, liver, thymus (BLT)
• mice average 1x106 human leukocytes/mL blood 12 weeks after transplantation and levels remain stable or improve through 21 weeks
• >80% of leukocytes in peripheral circulation are human
• transplanted mice have higher levels of multipotent bone marrow/hematopoietic stem cells than mice heterozygous for the Cd47tm1Fpl allele
• GVHD is not evident in mice 25 weeks post-transplantation
• human thymic organoids are highly vascularized
• large and small intestines of transplanted mice contain CD4+ and CD8+ human T cells
|
hematopoietic system
|
• HIV-infected BLT transplanted mice exhibit a loss of CD4+ T cells and an increase in CD8+ T cells
|
|
• a high proportion of CD38+ CD8+ T cells appear activated in HIV-infected BLT transplanted mice
|
|
• spleen and lymph nodes lack lymphocytes
|
|
• HIV-infected BLT transplanted mice exhibit a loss of CD4+ T cells and an increase in CD8+ T cells
|
