Phenotypes for Apc Bmi1 Tg(Vil1-cre)20Syr MGI:5532577 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Bmi1^tm1.1Lees/Bmi1^tm1.1Lees Apc^tm2Cip/Apc⁺ Tg(Vil1-cre)20Syr/0
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm2Cip mutation (0 available); any Apc mutation (156 available)
Bmi1^tm1.1Lees mutation (1 available); any Bmi1 mutation (31 available)
Tg(Vil1-cre)20Syr mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased alimentary system tumor incidence ( J:204354 )

• reduced visible and total lesions in the small intestine

decreased colon tumor incidence ( J:204354 )

decreased intestinal adenoma incidence ( J:204354 )

digestive/alimentary system

decreased alimentary system tumor incidence ( J:204354 )

• reduced visible and total lesions in the small intestine

decreased colon tumor incidence ( J:204354 )

decreased intestinal adenoma incidence ( J:204354 )

cellular

cellular phenotype ( J:204354 )

N	• no increase in apoptosis is observed in non tumor tissue

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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