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Phenotypes Associated with This Genotype
Genotype
MGI:5532576
Allelic
Composition		 Bmi1tm1Brn/Bmi1tm1Brn
Apctm2Cip/Apc+
Cdkn2atm1Cjs/Cdkn2atm1Cjs
Tg(Vil1-cre)20Syr/0
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm2Cip mutation (0 available); any Apc mutation (156 available)
Bmi1tm1Brn mutation (2 available); any Bmi1 mutation (31 available)
Cdkn2atm1Cjs mutation (7 available); any Cdkn2a mutation (67 available)
Tg(Vil1-cre)20Syr mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
cachexia ( J:204354 )
• found in some animals by 90 days of age

behavior/neurological
hunched posture ( J:204354 )
• hunching appears in some animals at 90 days of age

neoplasm
increased intestinal adenoma incidence ( J:204354 )
• increased size and number of small intestine adenomas

digestive/alimentary system
increased intestinal adenoma incidence ( J:204354 )
• increased size and number of small intestine adenomas

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory