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Phenotypes Associated with This Genotype
Genotype
MGI:5532574
Allelic
Composition
Bmi1tm1Brn/Bmi1tm1Brn
Apctm2Cip/Apc+
Tg(Vil1-cre)20Syr/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm2Cip mutation (0 available); any Apc mutation (156 available)
Bmi1tm1Brn mutation (2 available); any Bmi1 mutation (31 available)
Tg(Vil1-cre)20Syr mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• tumors in small intestine are almost absent at 120 days of age
• fewer and smaller tumors at 90 days of age as well
• decrease in numbers of tumors between 90 and 120 days
• no increase in tumor size between 90 and 120 days
• also reduced at 120 days
• adenomas are one tenth the size of those found in controls at 120 days of age
• increased cell proliferation in adenomas at 90 days
• increased apoptosis in smaller adenomas but not larger ones at 90 days
• apoptosis is also increased in non tumor tissue

cellular
• increased apoptosis in smaller adenomas but not larger ones at 90 days
• apoptosis is also increased in non tumor tissue

digestive/alimentary system
• tumors in small intestine are almost absent at 120 days of age
• fewer and smaller tumors at 90 days of age as well
• decrease in numbers of tumors between 90 and 120 days
• no increase in tumor size between 90 and 120 days
• also reduced at 120 days
• adenomas are one tenth the size of those found in controls at 120 days of age
• increased cell proliferation in adenomas at 90 days
• increased apoptosis in smaller adenomas but not larger ones at 90 days
• apoptosis is also increased in non tumor tissue


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory