Phenotypes for Braf Cdkn2a Tg(Vil1-cre)997Gum MGI:5528298 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Braf^tm1.1Brd/Braf⁺ Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn Tg(Vil1-cre)997Gum/0
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braf^tm1.1Brd mutation (0 available); any Braf mutation (62 available)
Cdkn2a^tm1.1Brn mutation (1 available); any Cdkn2a mutation (59 available)
Tg(Vil1-cre)997Gum mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased intestinal adenoma incidence ( J:199307 )

• 1.3 fold increase in serrated adenomas relative to mice with unmutated Cdkn2a alleles (not statistically significant)

increased carcinoma incidence ( J:199307 )

• 6.4 fold increase in carcinomas relative to mice with unmutated Cdkn2a alleles

digestive/alimentary system

increased intestinal adenoma incidence ( J:199307 )

• 1.3 fold increase in serrated adenomas relative to mice with unmutated Cdkn2a alleles (not statistically significant)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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