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Phenotypes Associated with This Genotype
Genotype
MGI:5528297
Allelic
Composition		 Braftm1.1Brd/Braf+
Tg(Vil1-cre)997Gum/0
Trp53tm2Tyj/Trp53tm2Tyj
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1.1Brd mutation (0 available); any Braf mutation (62 available)
Tg(Vil1-cre)997Gum mutation (2 available)
Trp53tm2Tyj mutation (2 available); any Trp53 mutation (236 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
abnormal tumor pathology ( J:199307 )
• invasiveness of cancers considerably increased
• 56% of mice at 10-20 months
increased metastatic potential ( J:199307 )
• 25% of cancerous mice have metastases

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory