Phenotypes Associated with This Genotype

Genotype
MGI:5528296

• Allelic Composition: Braf^tm1.1Brd/Braf⁺; Tg(Vil1-cre)997Gum/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestinal epithelium morphology ( J:199307 )

abnormal intestinal mucosa morphology ( J:199307 )

• increased number of proliferating cells (hyperproliferation) in the mucosa

• levels of apoptosis are unchanged

abnormal crypts of Lieberkuhn morphology ( J:199307 )

• generalized crypt hyperplasia affecting almost all crypts

abnormal large intestine crypts of Lieberkuhn morphology ( J:199307 )

• crypt hyperplasia and mucosal protrusions

abnormal large intestine morphology ( J:199307 )

• significantly elongated and thickened

increased large intestine length ( J:199307 )

• significantly elongated

abnormal small intestine morphology ( J:199307 )

• significantly elongated and thickened

abnormal small intestinal villus morphology ( J:199307 )

• villi are thickened and deformed

branched small intestinal villi ( J:199307 )

• villi are often branched

increased small intestine length ( J:199307 )

• significantly elongated

intestine polyps ( J:199307 )

• focal serrated epithelial formations with cytomorphologic features of human microvesicular or goblet rich hyperplastic polyps

• predominantly in the small intestine

increased gastrointestinal tumor incidence ( J:199307 )

• macroscopic tumors and dysplasia in some mice at 2-3 months of age

• all mice with dysplastic lesions by 10 months

increased intestinal adenoma incidence ( J:199307 )

• dysplastic lesions in 10 month old mice with features of human serrated adenomas

• crypt elongation and serrated eosinophilic adenomatous epithelium

• only 5 of 95 tumors found were in the large intestine

• increased proliferation in murine adenoma with dysplasia

neoplasm

increased gastrointestinal tumor incidence ( J:199307 )

• macroscopic tumors and dysplasia in some mice at 2-3 months of age

• all mice with dysplastic lesions by 10 months

increased intestinal adenoma incidence ( J:199307 )

• dysplastic lesions in 10 month old mice with features of human serrated adenomas

• crypt elongation and serrated eosinophilic adenomatous epithelium

• only 5 of 95 tumors found were in the large intestine

• increased proliferation in murine adenoma with dysplasia

increased carcinoma incidence ( J:199307 )

• in 8.3% of mice under 10 months of age

• in 13.8% of mice older than 10 months

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:199307 )

• generalized crypt hyperplasia affecting almost all crypts

abnormal large intestine crypts of Lieberkuhn morphology ( J:199307 )

• crypt hyperplasia and mucosal protrusions