Phenotypes Associated with This Genotype

Genotype
MGI:5527535

• Allelic Composition: Dmrta2^tm1.2Fuma/Dmrta2^tm1.2Fuma
• Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Reduced cortical size of Dmrta2^tm1.2Fuma/Dmrta2^tm1.2Fuma newborn brains

nervous system

nervous system phenotype ( J:203109 )

N • midbrain size at P0 is normal

abnormal neuronal precursor proliferation ( J:203109 )

• decreased mitotic index

absent hippocampus ( J:203109 )

• almost disappeared

abnormal cerebral cortex morphology ( J:203109 )

• reduced area at P0

• severely disorganized medial cortex

• slight affect on the positioning of Ctip2+ neurons in layer II-IV

• increased density of late born neurons

small olfactory bulb ( J:203109 )

• without disruption in layer formation

telencephalon hypoplasia ( J:203109 )

• at E12.5 and P0

• however, size is normal at E10.5

decreased neuronal precursor cell number ( J:203109 )

• in the dorsal telencephalon

decreased neuron number ( J:203109 )

• in the cortex

• reduced number and density of early born neurons in the neocortex

cellular

abnormal neuronal precursor proliferation ( J:203109 )

• decreased mitotic index