Phenotypes Associated with This Genotype

Genotype
MGI:5525154

• Allelic Composition: Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho; Tg(Mx1-cre)1Cgn/?
• Genetic Background: involves: 129 * C57BL/6 * CBA/Ca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

abnormal induced morbidity/mortality ( J:201572 )

• most mice die 7-10 days after final dose of the immunostimulant dsRNA poly(I:C) as compared to controls

• lethality is a result severe anemia

hematopoietic system

abnormal definitive hematopoiesis ( J:201572 )

• hematopoietic stem and progenitor cell populations are distorted following final dose of poly(I:C)

abnormal common myeloid progenitor cell morphology ( J:201572 )

• increase in numbers of bipotential granulocytic/moncytic precursor cells following final dose of poly(I:C)

• accumulation of immature myeloid cells

decreased common myeloid progenitor cell number ( J:201572 )

• decrease in numbers of myeloid progenitors (Sca-1- cKit+, LS-K+) after final dose of poly(I:C)

decreased granulocyte number ( J:201572 )

• Gr1^high Mac1+ granulocytes are almost absent from bone marrow after final dose of poly(I:C)

decreased neutrophil cell number ( J:201572 )

• loss of mature neutrophils following final dose of poly(I:C)

decreased hematopoietic stem cell number ( J:201572 )

• decrease in numbers of hematopoietic stem cells and multipotent progenitors (Sca-1+ cKit+, LS+K+) 1 week after final dose of poly(I:C)

pancytopenia ( J:201572 )

• following final dose of poly(I:C)

increased hematopoietic stem cell number ( J:201572 )

• four fold increase in long term repopulating hematopoietic stem cell (LT-HSC) population (lin- CD150+ CD48- Sca-1+ c-Kit+) found in recombined cells

• immunophenotypic LT-HSC population exhibits 2-fold proliferation, but unaltered apoptosis levels

immune system

decreased granulocyte number ( J:201572 )

• Gr1^high Mac1+ granulocytes are almost absent from bone marrow after final dose of poly(I:C)

decreased neutrophil cell number ( J:201572 )

• loss of mature neutrophils following final dose of poly(I:C)