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Phenotypes Associated with This Genotype
Genotype
MGI:5524225
Allelic
Composition		 Fbxw7tm1Iaai/Fbxw7tm1Iaai
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7tm1Iaai mutation (1 available); any Fbxw7 mutation (81 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell differentiation ( J:200006 )
• pIpC-treated mice exhibit depletion of early T cell progenitors in the thymus
decreased hematopoietic stem cell number ( J:200006 )
• in the bone marrow of pIpC-treated mice
abnormal hematopoietic stem cell physiology ( J:200006 )
• less functionally competent than in cells from pIpC-treated mice Fbxw7tm2Iaai/Fbxw7+ Tg(Mx1-cre)1Cgn mice

immune system
abnormal T cell differentiation ( J:200006 )
• pIpC-treated mice exhibit depletion of early T cell progenitors in the thymus

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory