Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fbxw7tm2Iaai
Name:	F-box and WD-40 domain protein 7; targeted mutation 2, Iannis Aifantis
MGI ID:	MGI:5524152
Synonyms:	Fbxw7R468Neo
Gene:	Fbxw7  Location: Chr3:84722575-84886505 bp, + strand  Genetic Position: Chr3, 37.7 cM, cytoband E3.3
Alliance:	Fbxw7tm2Iaai page

Germline Transmission:	Earliest citation of germline transmission: J:200006
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutations:    Insertion, Nucleotide substitutions   Mutation details: Exon 11 was replaced with a floxed neomycin resistance cassette and a modified exon 11 in which nucleotide substitutions (CGG to TGC) result in the amino acid substitution of cysteine for arginine at position 468 (R468C). (J:200006)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fbxw7 Mutation:	82 strains or lines available

Original:	J:200006 King B, et al., The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability. Cell. 2013 Jun 20;153(7):1552-66
All:	1 reference(s)