Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7tm2Iaai mutation
(0 available);
any
Fbxw7 mutation
(82 available)
|
|
|
mortality/aging
|
|
• no mice are recovered from breeding heterozygotes
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7tm2Iaai mutation
(0 available);
any
Fbxw7 mutation
(82 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
|
|
|
neoplasm
|
N |
• pIpC-treated mice do not develop leukemia
|
|
|
• pIpC-treated mice infected with a retrovirus expression a truncated form of Notch1 that is constitutively cleaved in a ligand-independent manner or a Notch1 lacking the PEST domain exhibit shorted latency to development of leukemia
|
hematopoietic system
|
N |
• pIpC-treated mice exhibit normal numbers of hematopoietic stem cells and are more functionally competent than in cells from Fbxw7tm1Iaai/Fbxw7 + Tg(Mx1-cre)1Cgn mice
|
immune system
|
N |
• pIpC-treated mice exhibit normal numbers of early T cell progenitors in the thymus
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7tm2Iaai mutation
(0 available);
any
Fbxw7 mutation
(82 available)
Tg(EIIa-cre)C5379Lmgd mutation
(4 available)
|
|
|
embryo
|
N |
• mice do not develop developmental defects
|
neoplasm
|
N |
• mice do not develop tumors
|
Analysis Tools
