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Phenotypes Associated with This Genotype
Genotype
MGI:5519974
Allelic
Composition
Bscl2tm1Geno/Bscl2tm1Geno
Genetic
Background
B6.129P2-Bscl2tm1Geno
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bscl2tm1Geno mutation (0 available); any Bscl2 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• while mice are present in Mendelian ratios at E12, fewer than expected mice survive after weaning

reproductive system
• enlarged epididymal canal in male mice
• in male mice

homeostasis/metabolism
N
• fasted male mice exhibit normal serum cholesterol levels
• in male mice
• however, pioglitazone treatment improves phenotype
• in random-fed male mice starting at 9 weeks and worsening with age
• in 4 month old fasted male mice
• however, pioglitazone treatment improves phenotype
• at 2 months in male mice
• however, pioglitazone treatment improves phenotype
• in male mice
• however, pioglitazone treatment improves phenotype
• in male mice
• however, pioglitazone treatment improves phenotype
• in male mice
• however, pioglitazone treatment improves phenotype
• in 4 month old male mice
• in 4 month old male mice
• however, pioglitazone treatment improves insulin sensitivity
• at 2 months in the serum of male mice
• however, pioglitazone treatment improves phenotype
• male mice exhibit increased triacylglycerol-rich lipoprotein clearance compared with wild-type mice
• hepatic lipid uptake in male mice is increased compared to in wild-type mice
• however, pioglitazone treatment improves lipid homeostasis
• fasted male mice at 2 months
• however, random fed mice exhibit normal levels
• fasted and random-fed male mice at 2 months
• in male mice
• however, pioglitazone treatment improves phenotype
• mouse embryonic fibroblasts exhibit a 4-fold increase in basal glycerol release indicating increased basal lipolysis compared with wild-type cells
• however, isoprenaline-stimulated lipolysis is normal

adipose tissue
• in male mice
• however, pioglitazone treatment improves phenotype
• following induction of adipocyte differentiation, mouse embryonic fibroblasts exhibit reduced triacylglycerol levels compared with wild-type cells
• however, thiazolidinediones partially restore adipocyte function in vitro
• absent peri-gonadal fat pad in male mice
• in male mice
• however, pioglitazone treatment improves phenotype
• in male mice
• however, pioglitazone treatment improves phenotype
• near total in 2 month old male mice

liver/biliary system
• in male mice
• however, pioglitazone treatment improves phenotype
• in male mice
• 2-fold in male mice
• however, pioglitazone treatment improves phenotype
• in male mice
• however, pioglitazone treatment improves phenotype

growth/size/body
• in mice treated with pioglitazone
• however, untreated mice exhibit normal body weight

behavior/neurological
N
• male mice exhibit normal activity levels
• at 2 months in male mice

digestive/alimentary system
• enlarged in male mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congenital generalized lipodystrophy type 2 DOID:0111136 OMIM:269700
J:200947


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/12/2020
MGI 6.15
The Jackson Laboratory