Phenotypes Associated with This Genotype

Genotype
MGI:5517353

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Ptpn22*)Draw}/Gt(ROSA)26Sor⁺; Cd19^tm1(cre)Cgn/Cd19⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Renal abnormalities in Gt(ROSA)26Sor^{tm1(Ptpn22*)Draw}/Gt(ROSA)26Sor⁺ Cd19^tm1(cre)Cgn/Cd19⁺ mice

immune system

enlarged spleen ( J:201448 )

• at 10 months

spleen hyperplasia ( J:201448 )

• at 10 months

increased B cell number ( J:201448 )

• of age-dependent B cells

increased germinal center B cell number ( J:201448 )

• in aged mice

increased autoantibody level ( J:201448 )

• broad range of autoantibodies in aged mice

increased anti-double stranded DNA antibody level ( J:201448 )

• in aged mice

glomerulonephritis ( J:201448 )

• in aged mice with increased cellularity and mesangial matrix and infiltration of Mac1+ cells

renal/urinary system

glomerulonephritis ( J:201448 )

• in aged mice with increased cellularity and mesangial matrix and infiltration of Mac1+ cells

expanded mesangial matrix ( J:201448 )

• in aged mice

hematopoietic system

enlarged spleen ( J:201448 )

• at 10 months

spleen hyperplasia ( J:201448 )

• at 10 months

increased B cell number ( J:201448 )

• of age-dependent B cells

increased germinal center B cell number ( J:201448 )

• in aged mice

growth/size/body

enlarged spleen ( J:201448 )

• at 10 months

spleen hyperplasia ( J:201448 )

• at 10 months