mortality/aging
• no mice survive beyond P28
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• mice begin to die around P17
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nervous system
• in the dentate granule cell layer
• however, no increase in astrocytic differentiation is observed in the dentate gyrus
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• expansion of the pool of proliferating hippocampal progenitor cells in the third postnatal week
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• at P10 and P20
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• reduced volume of the dentate granule cell layer
• reduced volume at P21 but not P12
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• cytoarchitectonic alterations affecting all lobes at P21
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• irregular positions in the flocculonodular lobe LX
• Purkinje cells appear elongated
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• reduced and irregular arborization in the cerebellar molecular layer with more than 2 times lengthening of primary dendrite length
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• in the flocculonodular lobe LX
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• reduced and irregular arborization in the cerebellar molecular layer with more than 2 times lengthening of primary dendrite length
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• reduced glomeruli size indicating that the synapses of the granule cells with mossy fiber and Golgi cells do not form correctly
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• reduced length with less well demarcated and fuzzy border
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• reduced length with less well demarcated and fuzzy border
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• reduced length
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• reduced length
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• less well demarcated and fuzzy border
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• ced length with less well demarcated and fuzzy border and disorganized glomeruli
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• at P21
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behavior/neurological
• autoaggression (biting of their toes) in 13 of 15 mice
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• impaired ability to walk and balance on a rod
• however, mice walk normally otherwise
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• impaired ability to walk and balance on a rod
• however, mice walk normally otherwise
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growth/size/body
• at P5
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cellular
• in the dentate granule cell layer
• however, no increase in astrocytic differentiation is observed in the dentate gyrus
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• expansion of the pool of proliferating hippocampal progenitor cells in the third postnatal week
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