Phenotypes for Kras Pdpk1 Ptf1a MGI:5510701 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Kras^tm4Tyj/Kras⁺ Pdpk1^tm1Mlw/Pdpk1^tm1Mlw Ptf1a^tm1(cre)Hnak/Ptf1a⁺
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (12 available); any Kras mutation (88 available)
Pdpk1^tm1Mlw mutation (0 available); any Pdpk1 mutation (139 available)
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreas morphology ( J:197054 )

• pancreas of older mice exhibit some areas of fatty degeneration

• however, acinar to ductal metaplasia observed in acini from Kras^tm4Tyj Ptf1a^tm1(cre)Hnak double heterozygotes is rescued in an in vitro assay

neoplasm

neoplasm ( J:197054 )

N	• pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma observed in Kras^tm4Tyj Ptf1a^tm1(cre)Hnak double heterozygotes is rescued

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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