Phenotypes Associated with This Genotype

Genotype
MGI:5510694

• Allelic Composition: Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa}/Gt(ROSA)26Sor⁺; Ptf1a^tm1(cre)Hnak/Ptf1a⁺
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

enlarged pancreas ( J:197054 )

increased pancreas weight ( J:197054 )

increased pancreatic ductal adenocarcinoma incidence ( J:197054 )

• phenocopies metastatic pancreatic ductal adenocarcinoma that develops in mice expressing with Kras^tm4Tyj activated in the pancreas

increased pancreatic intraepithelial neoplasia incidence ( J:197054 )

• in all mice as early as 1 month with progression in amount and grade over time

pancreatic acinar-to-ductal metaplasia ( J:197054 )

• massive induction of acinar to ductal metaplasia

neoplasm

increased pancreatic intraepithelial neoplasia incidence ( J:197054 )

• in all mice as early as 1 month with progression in amount and grade over time

increased carcinoma incidence ( J:197054 )

• pancreatic carcinoma in situ in some mice at 9 months

increased pancreatic ductal adenocarcinoma incidence ( J:197054 )

• phenocopies metastatic pancreatic ductal adenocarcinoma that develops in mice expressing with Kras^tm4Tyj activated in the pancreas

growth/size/body

enlarged pancreas ( J:197054 )

increased pancreas weight ( J:197054 )