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Phenotypes Associated with This Genotype
Genotype
MGI:5506905
Allelic
Composition		 Pik3catm1Jjz/Pik3catm1Jjz
Ptentm1Hwu/Ptentm1Hwu
Tg(KRT14-cre)#Smr/0
Genetic
Background		 FVB.Cg-Pik3catm1Jjz Ptentm1Hwu Tg(KRT14-cre)#Smr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3catm1Jjz mutation (1 available); any Pik3ca mutation (66 available)
Ptentm1Hwu mutation (17 available); any Pten mutation (86 available)
Tg(KRT14-cre)#Smr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
thick epidermis stratum basale ( J:199362 )
• expanded basal cell layers
skin lesions ( J:199362 )
• development of skin lesions is delayed and severity is reduced compared to single Pten mutants
thick skin ( J:199362 )
• skin is thickened at 8 weeks of age, but to a lesser extent than in single Pten mutants
increased skin hamartoma incidence ( J:199362 )
• develop skin hamartomas with a median latency of 121 days

neoplasm
increased skin hamartoma incidence ( J:199362 )
• develop skin hamartomas with a median latency of 121 days

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory