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Phenotypes Associated with This Genotype
Genotype
MGI:5502699
Allelic
Composition		 Tab2tm2.1Aki/Tab2tm2.1Aki
Tab3tm1Aki/Tab3tm1Aki
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Tab2tm2.1Aki mutation (0 available); any Tab2 mutation (31 available)
Tab3tm1Aki mutation (0 available); any Tab3 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B-1a cell number ( J:195289 )
• peritoneal B-1a cell numbers are further reduced over reduction seen in Tab2 KO mice
decreased plasma cell number ( J:195289 )
• plasma cell populations are reduced
increased B cell apoptosis ( J:195289 )
• undergo apoptosis more rapidly in response to CpG DNA and anti-IgM but not anti-CD40 stimulation
decreased B cell proliferation ( J:195289 )
• impaired proliferation in response to CpG DNA, anti-IgM, and anti-CD40 stimulation

cellular
increased B cell apoptosis ( J:195289 )
• undergo apoptosis more rapidly in response to CpG DNA and anti-IgM but not anti-CD40 stimulation
decreased B cell proliferation ( J:195289 )
• impaired proliferation in response to CpG DNA, anti-IgM, and anti-CD40 stimulation

hematopoietic system
decreased B-1a cell number ( J:195289 )
• peritoneal B-1a cell numbers are further reduced over reduction seen in Tab2 KO mice
decreased plasma cell number ( J:195289 )
• plasma cell populations are reduced
increased B cell apoptosis ( J:195289 )
• undergo apoptosis more rapidly in response to CpG DNA and anti-IgM but not anti-CD40 stimulation
decreased B cell proliferation ( J:195289 )
• impaired proliferation in response to CpG DNA, anti-IgM, and anti-CD40 stimulation

homeostasis/metabolism

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory